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Scientific Impact:
The Aponte Santiago Lab seeks to elucidate the role of calcium signals in brain development, offering insights into the molecular basis of developmental brain disorders. Using zebrafish as an accessible model for integrating molecular, cellular, and systems approaches, we are linking calcium signaling dynamics to long-term transcriptional changes. We addresses the central question in cell biology: how transient cellular signals lead to changes in cell state. Dissecting calcium-dependent gene expression across time and cell type, our lab will identify conserved regulatory mechanisms of calcium signaling and its role in cell type specification and brain development.
Characterizing calcium dependent gene expression programs and their roles in brain development
Experimental approach:
Transcriptomics analysis
Imaging: calcium sensor, in situ
CRISPR perturbations
pharmacology
Elucidating cell type-specific calcium signaling in the brain
Characterizing tissue specific transcriptional effectors downstream of calcium activation and establishing a census of Ca2+-signaling states: which cell types are active and when?
Defining the roles of conserved and disease-associated calcium signaling genes in brain development
CaMKopathies
Channelopathies
Relevance in: epilepsy, autism, and intellectual disability
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